Abstract
Method: In high fat diet induced obese rats, obesity-related characteristics, including body weight, serum biochemical parameterswere assessed. At the end of the experimental histological analysis were carried out. Obesity was induced in Wistar rats using a HFD for first 25days. Then from 25th day to 50th day of study F. racemosa is given in dose of 90 mg/kg and 270mg/kg along with HFD. On 0, 25th, 50th day, body weight, histological changes and other parameters were recorded. Result: Bark powder of F. racemosa significantly reduced the absolute body weight. Ingestion of HFD containing F. racemosa to rat exhibited reduction in lipid parameters. High dose (270 mg/kg b.w) of F. racemosa significantly reduced the levels of triglyceride and VLDL whereas there were few differences observed in LDL and cholesterol. Treatment groups do not exhibited any substantial decrease in BSL. Minimal changes (+1) are found in liver tissues of F. racemose and B. prionitis treated groups. Furthermore, there is a mild fatty deposition is found.Conclusion: The results imply that F. racemose (at higher dose 270 mg/kg body) has anti-obesity effects in obesity-induced rats.
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