Abstract
Tuberculosis accounted as a serious disease throughout the world, and nephrotoxicityis one of the most serious side effects of main anti-tuberculosis drugs. The objective of this study was to explore the nephro-protective potential of rosemary aqueous extract against Isoniazid®-induced nephrotoxicity. Adult male Wistar albino rats (150-170g) were randomly divided into four groups: 1) normal rats, 2) rats administrated with rosemary extract (440mg/kg/day), 3) rats received Isoniazid® (50mg/kg/day), and 4) rats treated with Isoniazid® in combination with rosemary extract. After eight weeks, the results revealed that rosemary extract along with Isoniazid® minimized the Isoniazid®-induced renal deterioration; this was evidenced by the significant reduction in serum levels of urea, creatinine, uric acid, TNF-α, IL-1β and Na+ as well as kidney MDA, nitric oxide and DNA fragmentation .This was matched with a marked enhancement in calcium and K+ serum levels. and so kidney GSH, and Na+/K+ ATPase activity. Moreover, the histopathological findings showed a potential protection as the extract succeeded in prevention of Isoniazid® induced tissue degenerations. In conclusion, rosemary extract could play a beneficial role for the prevention of Isoniazid®-nephrotoxicity via its anti-oxidative and anti-nitrosative voltage.
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call