ANTI-NEOPLASTIC TRANSDERMAL PATCHES: A NOVEL APPROACH FOR TARGETED DRUG DELIVERY USING NANOCARRIERS IN CANCER THERAPY

Abstract

Innovative Nano-carrier-based transdermal patches, a wonder of advanced technologies, have received overwhelming endorsement in medicinal applications primarily in the provision of anti-neoplastic drugs. The purpose of this study was to review the limitations of conventional therapeutic initiatives namely chemotherapy, having several adverse effects, including significant inflammation, toxicity, and discomfort. Antineoplastic transdermal patches can be used as a prophylactic treatment method to treat a variety of cancers through the skin. Novel transdermal methods and Nanocarrier formulations have evolved to resolve the skin constraints and delivering the active drug to the underlying tissue of the skin enabling access to the systemic absorption of drugs and eventually get within tumour cells by approaching different targeting mechanisms. The transdermal administration of antineoplastic drugs is a promising alternative for boosting site-specific application, minimizing adverse effects, hepatic first-pass metabolism and promoting therapeutic value. Furthermore, the utilization of nanocarriers serves as a permeation enhancer to broaden the spectrum of medicines accessible for transdermal administration that has emerged as a viable and intriguing option. This review examines the benefits of transdermal delivery for anti-neoplastic drugs to ensure a good insight into their effectiveness in terms of modern clinical demands, to present a highlighted overview of transdermal drug delivery, and seeks to better comprehend the nano-formulations employed in transdermal drug delivery system (TDDS). Conclusively, reflecting the framework for future research and promoting the chemotherapeutic use of transdermal delivery over conventional dosage forms.