Abstract
Background: This study aimed to evaluate the role of anti-MCV antibodies in the diagnosis of RA and correlate anti-MCV with other markers of disease activity. Subjects and methods: The study was carried out on 70 individuals, categorized as follows; 40 patients diagnosed as rheumatoid arthritis (RA) (Group I), 15 patients diagnosed as osteoarthritis disease (OA) (Group II) and their results were compared to 15 apparently healthy persons as control group (Group III). All participants were subjected to careful history taking, general examination, routine laboratory investigations, in addition to, anti-cyclic citrullinated peptide (anti-CCP) and anti-mutated citrullinated vimentin (anti-MCV) assays. Results: Anti-CCP and anti-MCV values were significantly higher in group I when compared to group II and III (Pvalue 27.5 U/ml at which Sensitivity was 99.1, Specificity was 93.3, PPV was 97.8 and NPV was 99.8. The AUC (area under the curve) value for anti-MCV was 0.997. There were highly significant positive correlations between anti-MCV, anti-CCP and ESR in group I (P-value<0.001 and 0.001). Anti-CCP and anti-MCV were significantly higher in RF positive patients compared to RF negative patients (P-values=0.005 and 0.011 respectively), while no significant differences in anti-CCP and anti-MCV were found between CRP positive and CRP negative patients in group I. Conclusion: Anti-MCV is an excellent marker for early diagnosis of RA with high sensitivity and specificity especially when other markers are negative. The use of anti-MCV and anti-CCP collectively give the best result for the diagnosis of rheumatoid disease.
Highlights
Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease characterized by chronic joint inflammation that often leads to destruction of bone and cartilage, affects women three times as men, and usually appears in middle age [1]. the etiology of RA remains unknown, it is widely accepted that multiple accumulative genetic and environmental factors are required between the initiation of self-peptide recognition, subsequent loss of tolerance, and the development of autoimmunity
Anti-MCV is an excellent marker for early diagnosis of RA with high sensitivity and specificity especially when other markers are negative
The use of anti-MCV and anti-CCP collectively give the best result for the diagnosis of rheumatoid disease
Summary
Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease characterized by chronic joint inflammation that often leads to destruction of bone and cartilage, affects women three times as men, and usually appears in middle age [1]. the etiology of RA remains unknown, it is widely accepted that multiple accumulative genetic and environmental factors are required between the initiation of self-peptide recognition, subsequent loss of tolerance, and the development of autoimmunity. Rheumatoid arthritis (RA) is a chronic systemic inflammatory autoimmune disease characterized by chronic joint inflammation that often leads to destruction of bone and cartilage, affects women three times as men, and usually appears in middle age [1]. Initially affecting the small joints of the hands, feet and wrists [2]. Rheumatoid factor and anti-cyclic citrullinated antibodies (antiCCP) have been shown to be present prior to the appearance of clinical symptoms of arthritis suggesting that the initial immune deregulation in RA occurs years before symptomatic disease [4]. This study aimed to evaluate the role of anti-MCV antibodies in the diagnosis of RA and correlate anti-MCV with other markers of disease activity
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