Abstract
e20624 Background: Due to increased numbers of young cancer patients, the impact of anti-cancer treatments on fertility has become a major public health concern. Despite mounting research on ovarian toxicity, there is paucity of data regarding reliable biomarkers of testicular toxicity. We aimed to characterize the role of AMH as a marker for chemotherapy-induced testicular toxicity in both preclinical and clinical settings. Methods: Male patients ( < 45y) who were candidate for chemotherapy were enrolled into the study. Serum AMH and a panel of gonadal hormones were measured at baseline and post-treatment. In the preclinical setting, pubertal mice were injected with saline or various classes of chemotherapies and were sacrificed after 1week or 1/3/6 months post treatment. We evaluated compartments of spermatogenesis by AMH (both proteomics and real-time PCR), as well as qualitative and quantitative sperm parameters. Results: Nineteen patients were enrolled, median age was 38y (21-44y).Serum AMH was corre...
Published Version
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