Anti-inflammatory therapy of viral pneumonia on the model of chicken infectious bronchitis

Abstract

The effect of the drug Lumantse on the infectious bronchitis virus of chickens was evaluated. Infectious bronchitis of chickens is a highly contagious disease characterized by damage to the respiratory system and reproductive organs in young animals caused by a virus of the genus Gamma-coronavirus. The condition of the respiratory system caused by the infectious bronchitis virus (IBD) in chickens has much in common with the pathology of the respiratory system caused by SARS-CoV-2 in humans. For broilers, the course of IBD is characterized more often with damage to the respiratory system, manifested by bronchitis, pneumonia, tracheitis, as well as with kidney damage in the case of circulation of nephropathogenic strains. The effectiveness of the virocidal drug Lumantse was tested on 14-day-old cross shawer chickens infected with a ten-fold dose of the Nobilis IB Ma5 vaccine strain against infectious chicken bronchitis. The results of the studies showed that when the immune system is actively stimulated, the inflammatory response increases, with a simultaneous drop in the viral load, which is why a significant percentage of lung inflammation (60%) was observed in the experimental group. Compared with the control group, when using the drug Lumantse, there is a lower number of inflammatory reactions of the lungs, thymus by 40%, as well as the lowest concentration of viral particles in the lungs and intestines.