Abstract
The present study was undertaken to evaluate the anti-inflammatory potential of Murraya koenigii root extracts petroleum ether, ethyl acetate and chloroform (MKPE, MKEA and MKCF, respectively) and Ficus lacor aerial root extracts petroleum ether, ethyl acetate, chloroform and ethanol (FLPE , FLET, FLCF and FLET, respectively) at doses of 50 and 100 mg/kg body weight (b.w.) using animal models of acute inflammation (carrageenan-, histamine- and serotonin-induced inflammation). The results of the Murraya koenigii roots chloroform extract caused 66.4% inhibition and the ethanol extract of Ficus lacor aerial roots caused 68.3% inhibition at the dose of 50 mg/kg b.w. At a higher dose of 100 mg/kg b.w., MKPE and MKCF showed 55.10% and 70.10% inhibition, respectively. FLPE and FLET showed 74.50% and 75.40% inhibition, respectively, in the carrageenan-induced inflammation model. In histamine-induced inflammation, the MKCF showed 60% inhibition, and 67.01% and 68.02% inhibition with the petroleum ether and ethanol extracts, respectively, in Ficus lacor aerial roots at the dose of 50 mg/kg b.w. At a higher dose (100 mg/kg b.w.), MKCF showed 64% inhibition. FLPE and FLET showed 70.13%and 74.01% inhibition, respectively; 62.15% and 66.10% inhibition was observed with the petroleum ether and ethanol extracts of Ficus lacor aerial roots at 50 mg/kg b.w. At higher dose (100 mg/kg b.w.), FLPE and FLET showed 69.10% and 68.72% inhibition in serotonin-induced inflammation.
Highlights
Inflammation is a complex biological process involving several chemical mediators that are induced by the vascular tissue of the body when it comes in contact with harmful stimuli such as pollens, irritants, pathogens and damaged cells
Anti-inflammatory drugs of synthetic origin are classified as steroidal and nonsteroidal anti-inflammatory agents. The origin of these chemical compounds started when salicylates were isolated from the leaf extract of willow bark (Salix alba) and were used by the people of North America in 200 BC; they are regarded as the first generation of anti-inflammatory agents (Rainsford and Whitehouse 1980)
The present study was undertaken to evaluate the anti-inflammatory potential of Murraya koenigii root extracts and aerial root extracts of Ficus lacor
Summary
Inflammation is a complex biological process involving several chemical mediators that are induced by the vascular tissue of the body when it comes in contact with harmful stimuli such as pollens, irritants, pathogens and damaged cells. Anti-inflammatory drugs of synthetic origin are classified as steroidal and nonsteroidal anti-inflammatory agents The origin of these chemical compounds started when salicylates were isolated from the leaf extract of willow bark (Salix alba) and were used by the people of North America in 200 BC; they are regarded as the first generation of anti-inflammatory agents (Rainsford and Whitehouse 1980). Murraya koenigii Linn (Rutaceae), commonly known as Meethi neem, is an aromatic, deciduous shrub, found throughout India (Pande et al, 2009) In traditional medicine, it is used as an antiemetic, antidiarrheal, anti-dysentery, febrifuge, blood purifier, tonic, stomachic, flavoring agent in curries and chutneys (Prajapati et al, 2003). The present study was undertaken to evaluate the anti-inflammatory potential of Murraya koenigii root extracts and aerial root extracts of Ficus lacor
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