Abstract
Introduction: Lippia origanoides Kunth is an aromatic shrub known as “salva-do-marajo”. Aerial parts are used to treat gastrointestinal and respiratory problems and by Oriximina (PA, Brazil) midwife to treat postpartum bleeding (“to clean woman inside”) or to woman inflammation [1]. Although there are ethnobotanical data, there is no scientific evidence of information obtained. In this regard this work aimed to evaluate the effects of ethanol extract from leaves of L. origanoides in models of inflammation. Methods: L. origanoides was collected at Embrapa Amazonia Ocidental. Voucher (CESJ39532) is deposited at herbarium of Federal University of Juiz de Fora, Brazil. Leaves were dried, triturated and extracted by maceration with ethanol (EE). Webster mice (20 – 25 g, n = 6 – 8) were orally treated with EE (10, 30,100 mg/kg). Anti-inflammatory effect was evaluated by formalin [2] or subcutaneous air pouch (SAP) [3]. Results are presented as medium ± DP. Statistics was done by ANOVA/Bonferroni (*p < 0.05). Protocols for animal use number is #ICBDFBC-015 (COBEA/UFRJ/Brazil). Results: Conclusion: Ethanol extract from leaves of L. origanoides has a significant anti-inflammatory effect confirming the traditional use. Acknowledgements: Alan Minho (technical support), Instituto Vital Brazil (donation of animals), CAPES, CNPq and FAPERJ (financial support). Keywords: Lippia origanoides, anti-inflammatory effect
Published Version
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