Abstract
Compared with proinflammatory processes in the development of type 2 diabetes, our knowledge on anti-inflammatory cytokines is rather limited. Anti-inflammatory cytokines such as adiponectin, interleukin 1 receptor antagonist(IL-1RA), transforming growth factor-β1(TGF-β1), growth differentiation factor-15(GDF-15), omentin, and secreted frizzled-related protein 5 (SFRP5) are strongly associated with increased risk of type 2 diabetes: Adiponectin and omentin levels decreased before type 2 diabetes, in contrast, concentrations of IL-1RA, TGF-β1, GDF-15 are increased. Change of SFRP5 levels in impaired glucose tolerance and type 2 diabetes remains controversial. This paper will summarize and recommend studies that investigated associations between circulating levels of anti-inflammatory cytokines and type 2 diabetes. (Chin J Endocrinol Metab, 2015, 31: 375-378) Key words: Anti-inflammatory cytokines; Inflammatory; Diabetic mellitus, type 2
Published Version
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