Abstract
Objective To evaluate the anti–inflammatory and analgesic activities of leaf extract of Melanthera scandens ( M. scandens) Methods The crude leaf extract (39–111 mg/kg) of M. scandens was investigated for anti–inflammatory and analgesic activities using various experimental models. The anti–inflammatory activity was investigated using carragenin, egg-albumin induced oedema models, while acetic acid, formalin-induced paw licking and thermal-induced pain models were used to evaluate the antinociceptive property Results The extract caused a significant ( P<0.05 −0.001) dose-dependent reduction of inflammation and pains induced by different agents used. Conclusions The leaf extract possesses anti–inflammatory and analgesic effects which may be mediated through the phytochemical constituents of the plant.
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