Abstract
ObjectiveTo screen and evaluate the anti-inflammatory activity of methanolic and aqueous extracts of root, leaves and stem of Dipteracanthus patulus (Jacq.) Nees in animal models to support its traditional uses. MethodsThe anti-inflammatory activity using carrageenan was examined. Acute paw edema was induced by injecting 0.1 mL of 1 % (w/v) carrageenan solution, prepared in normal saline in sub-plantar region of the left hind paw of the rat. Measurements were taken at 0, 1, 2, 3 & 4 hours after the administration of the carrageenan. The extract which showed best activity were further evaluated by egg white, xylene and TPA (12-O-tetradecanoylphorbol-13-acetate) induced inflammation in rat models. ResultsMethanolic extract (26.4%) and aqueous extract (22.8%) of stem showed the best anti-inflammatory activity in carrageenan induced paw edema as well as in the other methods at a dose of 250 mg/kg body weight. ConclusionsPresent study, for the first time, confirms the significant anti-inflammatory activity potential of methanolic and aqueous extracts of stem of Dipteracanthus patulus on animal models.
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