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Abstract
A new diarylpropane (1) along with seventeen known compounds (2–18), were extracted from the entire plant of Dianella ensifolia. The compounds 1–3 were identified as a distinctive group of diarylpropanes. Their structures were determined through comprehensive spectral analysis. An anti-inflammatory activity assay revealed that compound 7 demonstrated significant inhibitory effects on NO generation in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells, with an IC50 value of 9.93 μg/mL. Further in-depth mechanistic studies indicated that compound 7 suppresses LPS-induced NO production by inhibiting the activation of NF-κB, which subsequently led to a decrease in the expression of nitric oxide synthase enzymes (iNOS).
Published Version
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