Abstract
The present study was intended to evaluate Anti-inflammatory activity ofC. rottleriextracts (Hydroalcoholic, Methanol, Ethyl acetate and Hexane). The Anti-inflammatory activity ofC.rottleriextracts at doses of 125mg/kg, 250mg/kg and 500mg/kg using carrageenan induced rat paw edema model compared with standard drug (Indomethacin). The selected plant extracts significantly inhibited paw edema along with the standard drug Indomethacin. Of all extracts, methanol extract produced significant effect on reduction of increased paw thickness, hydro alcoholic and ethyl acetate extracts produced moderate percentage inhibition and hexane extract produced low level of percentage inhibition in reducing paw edema on carrageenan induced rats. In all extracts, methanol extract at a dose of 500mg/kg showed more percentage inhibition i.e . 53.47±2.19. From the results obtained during the study it is concluded thatC. rottlerihaving the bioactive molecule responsible for Anti-inflammatory activity by individually or by combination of different bio-active compounds present in it. Further is necessary for isolation and characterization of bioactive molecules which are responsible for the selected plant biological activities.
Highlights
The uses of plants in traditional medicine have been wide spread around the world since ancient time and still plants have unidentified bioactive molecules those are recently discovered and developed novel drugs from plants in recent times like anti-inflammatory, digestive, antinecrotic, neuroprotective, antimicrobial and hepatoprotective [1,2,3,4,5]
The results showed the ability of the model in detecting that the time course changes in the paw size was associated with carrageenan induced rat paw edema
The present study is an attempt to evaluate anti-inflammatory potential of C. rottleri extracts because people have been exploring the plants since the ancient times and have been trying to reduce the side effects and develop effective anti-inflammatory agents using different plant extracts and formulations [17]
Summary
The uses of plants in traditional medicine have been wide spread around the world since ancient time and still plants have unidentified bioactive molecules those are recently discovered and developed novel drugs from plants in recent times like anti-inflammatory, digestive, antinecrotic, neuroprotective, antimicrobial and hepatoprotective [1,2,3,4,5]. Medicinal plants have received much attention as a source for treatments of several diseases based on their traditional uses because of their less side effects compared to chemical therapeutics which are long term administration is required for treatments of chronic diseases causing various side effects. In this point of view, many researchers scientifically reporting the important bioactive molecules from plants based on their traditional uses by evaluating their biological activities [6,7,8]. The seeds are used as cathartic like Ghodtapde and credited with purgative properties [9,10,11,12,13,14]
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