Abstract
Essential oil extracted with supercritical CO2 fluid from the brown seaweed Undaria pinnatifida showed high anti-inflammatory activity. Optimal extraction with supercritical CO2 was observed at 45°C and 20 MPa. The essential oil was active against mouse ear inflammation induced by phorbol myristate acetate, with median inhibition concentration IC50 values of 87, 134, and 158 µg per ear for edema, erythema, and blood flow, respectively. The major component compounds were palmitic acid (26 %), 2-(9,12- octadecadienyloxy)-,(z,z)-ethanol (16 %), eicosa-5,8,11,14,17-pentaenoate (EPA; 13 %), and 5,7,11- eicosatrienoic acid (mead acid; 12 %). These findings are consistent with the claims that the seaweed U. pinnatifida can be used in remedies for inflammation-related symptoms.
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