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Abstract
Sida cordifolia is a shrub found throughout the tropical and sub-tropical plains. All parts of the plant are used as anti-rheumatic, antipyretic, anti-asthmatic, laxative, diuretic, vasorelaxative, hypotensive, central nervous system depressant, antioxidant, analgesic and hypoglycemic. The present study was aimed to evaluate the hypoglycemic, anti-hyperlipidemic and antioxidant potential of alcoholic-extract obtained from areal part of S. cordifolia in streptozotocin-induced-diabetes in wistar-rats. Diabetes was induced with streptozotocin at the intra-peritoneal dose of 55 mg/kg. Diabetic rats were treated with alcoholic extract of S. cordifolia at dosage of 200, 400 mg/kg and glibenclamide (5 mg/kg) after sub-acute administration for 28 days. Alcoholic extract of S. cordifolia at 400 mg/kg significantly improved the body-weight whereas significantly decreased the blood glucose level in diabetic rats. However at 400 mg/kg, the alcoholic extract of S. cordifolia showed beneficial effect indicating significant decrease in total cholesterol, triglycerides, low density lipids, plasma-creatinine, plasma-urea nitrogen and lipid-peroxidation and a significant increase in high density lipid-level in diabetic rats. Interestingly at 400 mg/kg, a significant increase in antioxidant enzymes such as catalase and superoxide-dismutase-activity was seen in the diabetic rats. The dose 200 mg/kg of alcoholic extract of S. cordifolia showed non-significant change in diabetic rats. The above therapeutic-potential of alcoholic extract of areal parts of plant may be because of the presence of bioactive compounds such as glycosides, resins, alkaloids, sterols, saponins and flavonoids. Thus, the findings of the present study indicate that the alcoholic extract of S. cordifolia at dosage level of 400 mg/kg produces anti-diabetic effect in the streptozotocin-induced diabetes in wistar-rats.
Highlights
Diabetes mellitus (DM) is the most common endocrine disorder characterized by hyperglycemia resulting from defects either in insulin secretion or insulin action or both [1, 2]
The percent alcoholic extractability of S. cordifolia was 19.06 % (w/w) and extract revealed the presence of alkaloids, glycosides, saponins, sterols, resins, fixed oil and flavonoids
Treatment was given to group IV diabetic rats with alcoholic extract of S. cordifolia at the dose of 400 mg/kg which produced a significant decrease in blood glucose level on day 15 and 29 as compared to day 0
Summary
Diabetes mellitus (DM) is the most common endocrine disorder characterized by hyperglycemia resulting from defects either in insulin secretion or insulin action or both [1, 2]. Several conventional-drugs are available along with insulin but their prolonged use may lead to other complications like blurred vision, hypoglycemia and a lingering condition like coma [5, 6]. The antidiabetic-drugs such as modern oral hypoglycemic agents’ like sulphonyl-ureas (tolbutamide, glibenclamide) and insulin-sensitizer (troglitazone) are associated with various side effects [6]. To reduce its damaging property it is better to use conventional-drugs along with hypoglycemic-herbs [7]. Sida cordifolia (Linn.) a shrub belonging to the family Malvaceae, improves the diabetic conditions [10, 11]. It is found through out the tropical and sub tropical plains of India. Keeping the fact that diabetes is an emerging problem world-wide and is a major concern of developing countries like India; the present study was conducted with the aim to evaluate the anti-oxidative and anti-diabetic activity of S. cordifolia in streptozotocin (STZ) induced diabetes in wistar rats
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Schedule a callMore From: Proceedings of the National Academy of Sciences, India Section B: Biological Sciences
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