Abstract
Background/Aim: Free radicals have a role in the development of chronic gastritis. The aim of this study to know the effect and efficacy of rebamipide on free radicals in chronic gastritis. Method: Forty five patients in the division gastroenterology Cipto Mangunkusumo Hospital Jakarta 2009-2010 with moderate and severe gastritis endoscopically were included in this study. Before and after rebamipide treatment the patient were performed endoscopical examination and were taken 5 biopsies for histopathological examination and free radicals (MDA & Carbonyl Compound) examination. All patients were given rebamipide 100 mg three times a day for 28 days. Data were analyzed with t test or wilcoxon signed rank test. Exclusion: GERD, Peptic ulcer, PPI treatment, NSAID consumption etc. The symptoms were recorded on day-0 and day-28. The severity symptoms were measured by VAS. Result: The mucosal damage on day-0 was 2.268 ± 0.45 vs day-28 was 1.707 ± 0.78 (P P = 0.710) and corpus neutrophil: day-0: 0.12 ± 0.40 vs day-28: 0.07 ± 0.26 (P = 0.421). The mean endoscopical mucosal severity score was decreased significantly on day- 28 compared to day-0 (1.707 ± 0.78 vs 2.268 ± 0.45; P P = 0.047). The mean of carbonyl compound on day-0 was 4.14 ± 3.01 and on day-28 was 5.12 ± 2.71 (P = 0.642). Conclusion: Rebamipide significantly reduced the extend of symptoms associated with chronic gastritis. The improvement in symptoms was associated with the decreased of endoscopic severity score and the mean gastric mucosal malondialdehyde (MDA) significantly but not the histopathologic appearance and carbonyl compound.
Highlights
Chronic gastritis is an inflammatory condition of the gastric mucosa characterized by elementary lesions, whose extent and distribution are related to their etiology and host response.Chronic gastritis has a multietiopathogenic factors with dyspeptic syndrome
Rebamipide significantly reduced the extend of symptoms associated with chronic gastritis
The improvement in symptoms was associated with the decreased of endoscopic severity score and the mean gastric mucosal malondialdehyde (MDA) significantly but not the histopathologic appearance and carbonyl compound
Summary
Chronic gastritis is an inflammatory condition of the gastric mucosa characterized by elementary lesions, whose extent and distribution are related to their etiology and host response. Chronic gastritis has a multietiopathogenic factors with dyspeptic syndrome. It is widely accepted that a major underlying factor of this disorder is the generation of free radicals. There is substantial evidence that oxygen derived free radicals play an important role in the pathogenesis of the injury of various tissues, including the digestive system [1]. Helicobacter pylori and non steroidal anti-inflammatory drug (NSAID) are two major causes related to gastric injury. Helicobacter pylori plays an important role in the induction of chronic gastritis and has been accepted that there is a strong association between Helicobacter pylori-associated gastritis and gastric diseases including peptic ulcer and gastric cancer
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