Abstract
In the present study, we investigated the anti-fatigue activity in male Kunming mice of extracts of stem bark from Acanthopanax senticosus (ASSE) using a forced swimming test. Mice were divided into four groups (three ASSE administered groups and the control group). The control group were gavaged with distilled water and ASSE administered groups were gavaged with ASSE (100, 200 and 400 mg/kg). After four weeks, a forced swimming test was performed and the biochemical parameters related to fatigue were examined. The results suggested that ASSE could extend the swimming time to exhaustion of the mice, as well as increase the tissue glycogen contents, while decreasing the blood lactate and serum urea nitrogen contents. This indicated that ASSE had anti-fatigue activity and could elevate the exercise tolerance.
Highlights
Acanthopanax senticosus is an approximately two-meter high, hardy shrub native to the far eastern areas of the Russian taiga and the northern regions of China, Japan, and Korea [1]
The present study is to investigate anti-fatigue activity of extracts of stem bark from Acanthopanax senticosus using a forced swimming test in male mice
The body weights of the mice were measured after they were administrated with different doses of ASSE for four weeks
Summary
Acanthopanax senticosus ( known as Eleutherococcus senticosus or Ciwujia, and previously known as Siberian ginseng) is an approximately two-meter high, hardy shrub native to the far eastern areas of the Russian taiga and the northern regions of China, Japan, and Korea [1] It is known as an adaptogenic medicine, and it has been used as a crude drug to treat stress-induced physiological changes, various allergic conditions, inflammation and cancer [2,3,4,5,6]. The major active components of Acanthopanax senticosus include acanthoside, eleutheroside, chiisanoside, senticoside, triterpenic saponin, syringin, flavone, vitamin, minerals, β-sitosterol, sesamine and savinine [7,8,9]. The present study is to investigate anti-fatigue activity of extracts of stem bark from Acanthopanax senticosus using a forced swimming test in male mice
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