Abstract
Antiepileptic effects of both TRH tartrate (TRH-T) and its derivative, γ-butyrolactone-γ-carbonyl-L-histidyl-L-prolinamide citrate (DN-4417) have been evaluated using the amygdaloid kindling cat preparation. The results reported are: 1) transient anticonvulsant effects unrelated to dose for both TRH-T and DN-1417, 2) long-term elevation of the final electroconvulsive threshold in some cats after TRH-T and DN-1417 treatment, 3) prophylactic effects on kindling seizure development as well as effects to prevent positive transfer of the kindling to the contralateral amygdala after daily treatment with DN-1417, 4) a shortened postictal behavioral depression and EEG silence with DN-1417 and 5) a prolonged postictal seizure inhibition period with DN-1417. It is hypothesized that endogenous TRH inhibits seizure activity and reduces the establishment of epileptogenesis in the brain.
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