Anti-dyslipidemic properties of green gold nanoparticle: improvement in oxidative antioxidative balance and associated atherogenicity and insulin resistance

Reyhane Javanshir,Moones Honarmand,Mehran Hosseini,Mina Hemmati

doi:10.1186/s40816-020-00224-6

Abstract

BackgroundNowadays, the green synthesis of AuNPs in the presence of plants has been attracted a lot of attention. Herein, in vivo antidiabetic activity of AuNPs synthesized using Ziziphus jujuba in streptozotocin-induced diabetic rats has been evaluated.MethodsFormation of AuNPs was confirmed by UV-vis, HR-TEM and XRD. Different doses of jujube gold nanoparticles (0.5 and 1 mg/kg) were used to treat streptozotocin-induced diabetic rats in different groups. At the end of experiment (21 days), serum level of fasting blood glucose (FBG), insulin, Body weight, HOMA-IR, vitamin D, ALT, AST, urea, creatinine, lipid profile, prooxidant-antioxidant balance (PAB) and liver oxidative stress markers were determined.Resultsresults showed a significant decrease in the level of liver MDA (P = 0.001), fasting blood glucose (P = 0.0001), HOMA-IR (P = 0.0001), ALT (P = 0.0001), AST (P = 0.0001), urea (P = 0.02), Triglycerides (P = 0.002), Total cholesterol (P = 0.0001), PAB (P = 0.0001) and AIP (P = 0.001) and in contrast a significant increase total antioxidant capacity (P = 0.02), insulin (P = 0.03), Body weight (P = 0.0001) and vitamin D (P = 0.0001) in the AuNPs-treated diabetic group compared to the diabetic rats. No significant change was observed in the total thiol group (P = 0.18), LDL-C (P = 0.43), creatinine (P = 0.09) and HDL-C (P = 0.71) level in diabetic rats treated with AuNPs compared to diabetic rats.ConclusionThe results of this study proves that green AuNPs exerted promising antidiabetic and anti-oxidant properties.

Highlights

Diabetes mellitus (DM) is a growing problem around the world that requires financial and health care policies [1,2,3,4]
We introduced an easy and safe route for the biosynthesis of green AuNPs and therapeutic potential of the AuNPs in diabetes
Effect of AuNPs on blood glucose, insulin, Homeostasis Model Assessment of IR (HOMA-IR), body weight and vitamin D levels in diabetic rats According to the data obtained in this study, treatment of diabetic rats with AuNPs (1 mg/kg.b.w) for 21 days, improved glucose metabolism

Summary

Introduction

Diabetes mellitus (DM) is a growing problem around the world that requires financial and health care policies [1,2,3,4]. Many studies show the role of metals in development of drugs and glucose metabolism [5, 6]. The green synthesis of AuNPs in the presence of plants has received much attention [15,16,17,18]. One of plants that has fabulous medicine properties is Ziziphus jujuba (jujube). We introduced an easy and safe route for the biosynthesis of green AuNPs and therapeutic potential of the AuNPs in diabetes. The green synthesis of AuNPs in the presence of plants has been attracted a lot of attention. In vivo antidiabetic activity of AuNPs synthesized using Ziziphus jujuba in streptozotocin-induced diabetic rats has been evaluated

Methods

Results

Discussion

Conclusion