Abstract
<p>The purpose of this study was to investigate the anti-diabetic effect of crude <em>Pistacia lentiscus</em> gum (mastic gum) in alloxan-treated diabetic rat model. The crude <em>P. lentiscus</em> (100 mg/kg) showed significant (p&lt;0.001) reduction in blood glucose as compared to control. Liver function test also showed significant changes (p&lt;0.001) as compared to alloxan-treated group. The results of this study showed that crude <em>P. lentiscus</em> gum have considerable efficacy in curing diabetes and have hepatoprotective effect. </p><p> </p>
Highlights
Diabetes mellitus is a great healthcare problem in Asia as compared to rest of the world
Blood glucose levels in diabetic rats were significantly higher than treated group at 0,6,24 hour interval (p
In chronic administration of crude P. lentiscus showed highly significant decreased in blood glucose level (p
Summary
Diabetes mellitus is a great healthcare problem in Asia as compared to rest of the world. Herbal medicines are traditionally used for the treatment of diabetes mellitus. The resin of P. lentiscus referred to as “Arabic gum” or “mastic”. The leaf and other plant parts may contain compounds absent in the resin. It acts as an antioxidant (Hosseinzadeh et al, 2012; Koutsoudaki et al, 2005), used in the treatment of peptic ulcer (Huwez et al, 1998), mild effects against helicobacter pylori (Paraschos et al, 2007), chewing mastic can prevent tooth and gingivitis due to its antibacterial properties (Aksoy et al, 2006; Takahashi et al, 2003), in the preparation of bandages and skin ointments (Triantafyllou et al, 2007). Various activities of the plant have already been reported in ancient literature but its therapeutic potential is still lacking
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