Abstract
Objective:To find out the hypoglycemic and hypolipidemic activity of an ethanolic extract of the aerial part of Salvadora oleoides Decne in euglycemic and alloxan-induced diabetic albino rats.Materials and Methods:Diabetes was induced in albino rats by administration of alloxan monohydrate (120 mg/kg, i.p.). Normal as well as diabetic albino rats were divided into groups (n = 6) receiving different treatments: vehicle (control), ethanolic extract (1 g and 2 g/kg b.w), and standard antidiabetic drug tolbutamide (0.5 g/kg b.w.). Blood samples were collected by cardiac puncture and were analyzed for blood glucose and lipid profile on days 0, 7, 14, and 21.Results:The ethanolic extract of S oleoides produced significant reduction (P < 0.001) in blood glucose and also had beneficial effects (P < 0.001) on the lipid profile in euglycemic as well as alloxan-induced diabetic rats at the end of the treatment period (21st day). However, the reduction in the blood glucose and improvement in lipid profile was less than that achieved with the standard drug tolbutamide.Conclusion:We concluded that an ethanolic extract of S oleoides is effective in controlling blood glucose levels and improves lipid profile in euglycemic as well as diabetic rats.
Highlights
Hypoglycemic and hypolipidemic activity of ethanolic extract of Salvadora oleoides in normal and alloxan-induced diabetic rats
Blood samples were collected by cardiac puncture and were analyzed for blood glucose and lipid profile on days 0, 7, 14, and 21
The reduction in the blood glucose and improvement in lipid profile was less than that achieved with the standard drug tolbutamide
Summary
Diabetes was induced in albino rats by administration of alloxan monohydrate (120 mg/kg, i.p.). Normal as well as diabetic albino rats were divided into groups (n = 6) receiving different treatments: vehicle (control), ethanolic extract (1 g and g/kg b.w), and standard antidiabetic drug tolbutamide (0.5 g/kg b.w.). Adult albino rats of 16-19 weeks age and of either sex, weighing 180-200 g, were procured from the Disease-Free. The animals were kept in clean and dry plastic cages, with 12 h: 12 h light-dark cycle at 25 ± 2°C temperature and. The animals were fed with standard pellet diet (Hafed, Rohtak) and water was given ad libitum. For experimental purpose the animals were kept fasting overnight but allowed free access to water.
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