Abstract
The anticancer efficacy of 4H- Chromene Spirooxindole hybrid molecules 4i-m1 (Samples 1- 5) was investigated on Dalton’s lymphoma (non-Hodgkin lymphoma) cells. Dalton’s lymphoma (DL) is a spontaneous and highly invasive T-cell lymphoma that develops as an ascitic tumor in murines. It was observed that treatment of DL cells with compounds showed significant decrease in cell viability, altered morphology, nuclear disintegration and DNA fragmentation into low molecular weight DNA fragments and thus characteristic of apoptosis. In this view, these compounds may be used as potential therapeutic regimen to treat this type of cancer in experimental mice.
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