Abstract
How SARS-CoV-2 originated to cause the current pandemic is unknown. Although genetically similar coronaviruses have been identified in non-human animal reservoirs, no intermediate hosts have been identified. SARS-CoV-2 is a human-adapted virus and is anthroponotic. Considering that the virus has a broad host range, it is likely to adapt to other non-human animal hosts as it circulates more widely.1 A naturally occurring Asn501Tyr spike protein variation, as seen in the UK, South African, and Brazilian variants, has altered tropism and can now infect laboratory mice and rats.
Highlights
How SARS-CoV-2 originated to cause the current pandemic is unknown
Some might be more susceptible to severe disease than others
Given the biological similarity of great apes with humans, some evidence of safety and efficacy of first and new generations of vaccines in light of new variants could be extrapolated for use in great apes and species-specific adjuvants developed by Zoetis could be incorporated.[9]
Summary
How SARS-CoV-2 originated to cause the current pandemic is unknown. genetically similar coronaviruses have been identified in non-human animal reservoirs, no intermediate hosts have been identified. SARS-CoV-2 is a human-adapted virus and is anthroponotic.
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