Abstract
The interaction of anthrax toxin or toxin components with B. anthracis spores has been demonstrated. Germinating spores can produce significant amounts of toxin components very soon after the initiation of germination. In this review, we will summarize the work performed that has led to our understanding of toxin and spore interactions and discuss the complexities associated with these interactions.
Highlights
The interaction of anthrax toxin or toxin components with B. anthracis spores has been demonstrated
These observations suggested that the immune response resulting from such a vaccination could prevent lethal intoxication and potentially alter the earliest stages of the disease pathogenesis
Later work clearly demonstrated that ungerminated B. anthracis spores contained a detectable level of toxin components
Summary
The interaction of anthrax toxin or toxin components with B. anthracis spores has been demonstrated. One of the earliest reports of the phenomena resulting from spore and anti-toxin antibody interactions was published in 1996. These observations suggested that the immune response resulting from such a vaccination could prevent lethal intoxication and potentially alter the earliest stages of the disease pathogenesis (i.e., when the ungerminated spores are first introduced into the host).
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