Abstract

The Zika virus (ZIKV) is a neurotropic virus that can attack the central nervous system and cause microcephaly, neurodevelopmental impairment, and severe skeletal, hearing, and ocular abnormalities by vertical transmission. 1 de Paula Freitas B. de Oliveira Dias J.R. Prazeres J. et al. Ocular findings in infants with microcephaly associated with presumed Zika virus congenital infection in Salvador, Brazil. JAMA Ophthalmol. 2016; 134: 529-535 Crossref PubMed Scopus (416) Google Scholar , 2 Ventura C.V. Maia M. Bravo-Filho V. et al. Zika virus in Brazil and macular atrophy in a child with microcephaly. Lancet. 2016; 387: 228 Abstract Full Text Full Text PDF PubMed Scopus (392) Google Scholar , 3 Ventura C.V. Maia M. Ventura B.V. et al. Ophthalmologic findings in infants with microcephaly and presumable intra-uterus Zika virus infection. Arq Bras Oftalmol. 2016; 79: 1-3 Crossref PubMed Scopus (220) Google Scholar , 4 de Paula Freitas B. Ko A.I. Khouri R. et al. Glaucoma and congenital Zika syndrome. Ophthalmology. 2017; 124: 407-408 Abstract Full Text Full Text PDF PubMed Scopus (37) Google Scholar The wide range of congenital abnormalities associated with the vertical transmission of the ZIKV is referred to as “congenital Zika syndrome” (CZS).

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