Abstract
Stimulus control was established in rats using either 8-hydroxy-2-[di- n-propylamino]tetralin (DPAT) (0.2 mg/kg) or yohimbine (3 mg/kg). Tests were then conducted with purported antagonist at 5-hydroxytryptamine 1A (5-HT 1A) receptors. Drugs studied were NAN-190, [+/−]-pindolol, and [−]-alprenolol. In addition, each drug was characterized in terms of its affinity for 5- HT 1 A and α 2-adrenoceptors by means of radioligand binding techniques. None of the antagonists tested provided complete blockade of the stimulus effects of either DPAT or yohimbine. However, [+/−]-pindolol produced a statiscally significant intermediate degree of antagonism of both DPAT and yohimbine. The affinities of DPAT, yohimbine, and NAN-190 for the 5-HT 1A and α 2-adrenergic receptors, respectively, were sufficiently high to lead to some ambiguity of interpretation of the behavioral data. However, the results with [+/−]-pindolol, which has high affinity for the 5-HT 1A receptor (34 nM) and negligible affinity for the α 2-adrenoceptor (24,600 nM), indicate that a significant component of yohimbine-induced stimulus control is mediated by the 5-HT 1A receptor.
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