Abstract
This chapter discusses a study to analyze the antagonism of the myoneural activity of antibiotics, local anesthetics, and general anesthetics by 4-amlnopyrldlne (4-APYR). The experiments were carried out on the rat phrenic nerve hemidiaphragm preparation, suspended in mammalian Krebs' solution at 37°C aerated with 95% O2–5% CO2 and stimulated at 0.1 Hz directly or indirectly by supramaximal impulses of 2 and 0.2 ms, respectively. NM transmission was blocked by d-tubocurarine in the experiments with direct stimulation. The inhibitory effect of antibiotics and local anesthetics on P was greater during indirect than during direct stimulation. In contrast, halogenated inhalation anesthetics, halothane, enflurane, isoflurane, dantrolene, and verapamil were equally potent inhibitors of P during direct and indirect stimulation. During indirect stimulation, the myoneural effects of the aminoglycoside type antibiotics, such as neomycin, streptomycin, gentamycin, and kanamycin and except for tetracaine, those of the ester type local anesthetics, cocaine, procaine, and 2-chloroprocalne as well as those of the halogenated inhalation anesthetics were completely antagonized by 5 × l0−6 M 4-APYR.
Published Version
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