Abstract
2-Substituted imidazolines and structurally related compounds, have been tested as possible antagonists to the inhibitory actions of ATP and purinergic nerve stimulation in the guinea-pig taenia coli. Imidazole at neutral pH had no effect on these responses. High concentrations of phentolamine, antazoline, tolazoline and yohimbine strongly reduced the inhibitory responses to ATP and purinergic nerve stimulation but not the inhibitory responses to amyl nitrite. These results are consistent with the purinergic nerve hypothesis. However, it is unlikely that the imidazoline drugs are causing specific blockade of purinergic transmission since they are known to have a wide range of pharmacological actions.
Published Version
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