Antagonism of Propoxyphene Poisoning in Albino Mice with Nalorphine HCl, Methylene Blue, and Tolonium Chloride

Abstract

The intraperitoneal administration of propoxyphene HCI to albino mice at a dosage level of 200 mg./Kg. (LD99.5) was lethal to 98 per cent of the controls. The prophylactic subcutaneous administration of nalorphine HC1 alone, or in combination with either methylene blue or tolonium chloride, significantly increased the number of survivors with the greatest degree of protection being afforded by the nalorphine-dye combinations. The intraperitoneal administration of propoxyphene HCI to albino mice at a dosage level of 200 mg./Kg. (LD99.5) was lethal to 98 per cent of the controls. The prophylactic subcutaneous administration of nalorphine HC1 alone, or in combination with either methylene blue or tolonium chloride, significantly increased the number of survivors with the greatest degree of protection being afforded by the nalorphine-dye combinations.