Abstract
Many mature Leydig cells of adult mice contain annular nucleoli. In the cytoplasm of these cells, there is an abundance of agranular endoplasmic reticulum and its modifications, i.e. membranous whorls and double-walled tubules. By contrast, the cytoplasm of Leydig cells with compact nucleoli shows abundant free ribosomes and granular endoplasmic reticulum. It is assumed that the granular endoplasmic reticulum shifts to the agranular endoplasmic reticulum and its modifications during the differentiation of the Leydig cell. For the maturation of the Leydig cell the annular nucleoli may play an important role.
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