Annual report of Japanese Brain Bank Network for Neuroscience Research.

Abstract

All Japan Brain Bank Network (AJBBN) is in the process of establishment in close collaboration with the Japanese Society of Neuropathology (JSNP) AJBBN is the movement by patients, doctors and researchers for cure of intractable neurological and psychiatric disorders. We first established the Brain Bank for Aging Research at Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology in 2001, formed the Japanese Brain Bank Network for Neuroscience Research (JBBNNR) funded by MEXT in 2001 and, then, the Japanese Brain Bank Net (JBBN) funded by AMED in 2016. In Japan, brain banking is based on general autopsy and general pathological and neuropathological diagnosis by pathologists and neuropathologists. The Brain Bank Committee, JSNP, supervises activity of each brain bank. In 2012, we established the Brain Bank for Neurodevelopmental, Neurological and Psychiatric Disorders (BBNNPD) at Osaka University, the first university brain bank in Japan. BBNNPD collaborates National Hospital Organization (NHO) organized by MHLW including Osaka Toneyama Medical Center and Utano University. BBAR accumulates postmortem resource of central and peripheral nervous system and published the epidemiological study of Lewy body (LB) pathology among a Tokyo suburban elderly cohort, showing that one third of the Japanese aged population contained LB somewhere in the body. We also conducted central diagnosis of corticobasal degeneration with morphological evaluation, genomic study and western blot analysis and supported research use. AJBBN steadily expands its territory and will cover all area in Japan.