Abstract
AnnexinA2 is a member of the Annexin family that acts as a Ca2+-dependent phospholipid and membrane binding protein, which is associated with the survival and spread of multiple neoplasms. However, the function of AnnexinA2 in ovarian cancer progression remains unclear. In this study, we aimed to investigate the role and underlying molecular mechanism of AnnexinA2 in cell proliferation and invasion in ovarian cancer. We found that the mRNA expression of AnnexinA2 was upregulated in ovarian cancer tissues and cell lines. In the loss-of-function of AnnexinA2, β-catenin was indicated to be significantly suppressed and EMT constrained. Moreover, cell proliferation and invasion were both markedly inhibited by the downregulation of AnnexinA2. Additionally, the overexpression of β-catenin obviously reversed the effect of AnnexinA2 on EMT, and cell proliferation and invasion, indicating that AnnexinA2 suppression regulated EMT through controlling β-catenin. Taken together, this study showed that AnnexinA2 inhibition suppresses proliferation and invasion in ovarian cancer via β-catenin/EMT, proposing the potential role of AnnexinA2 in the prevention and treatment of ovarian cancer.
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