Análisis de los factores radio-patológicos y terapéuticos del cáncer de mama triple negativo y su influencia en la recidiva y supervivencia libre de enfermedad

Abstract

ObjectiveTo analyse the association between breast density, lymphovascular invasion, microglandular adenosis and the axillary node status of triple-negative tumours (TN) with tumour recurrence and disease-free survival. To study whether tumour perfusion in MRI staging correlates with tumour recurrence, disease-free survival or diffusion restriction. To analyse whether the administration of neoadjuvant chemotherapy (NC) or the type of surgical treatment (breast-conserving surgery or mastectomy) are associated with a worse prognosis. Patients and methodsA retrospective study of mammograms and staging MRIs was performed from 2007 to 2014, including 122 women with TN breast cancer. Breast density was assessed in mammographic studies performed at the time of diagnosis. Lymph node status was analysed in biopsy or surgical specimens, whereas lymphovascular invasion and microglandular adenosis were studied only in surgical specimens. ResultsBreast density and histopathological factors were not associated with tumour recurrence. The maximum enhancement values in the dynamic sequence were higher in patients without tumour recurrence (P=.028), without demonstrating a relationship with diffusion restriction. ConclusionsTumours with higher values of internal enhancement showed less tumour recurrence. There was no correlation between the values of internal tumour enhancement and diffusion restriction. No prognostic association was observed with the remaining radiopathological factors.