Abstract
As a result of environmental factors, cadmium (Cd)
 taken into the body causes damage to lung tissues
 through inflammation, oxidative stress, and increased
 apoptosis. Ankaferd Blood Stopper (ABS), which is
 used as a hemostatic agent, has antioxidant, antiinflammatory,
 antibacterial, antiapoptotic, and wound
 healing properties due to five different plant extracts
 and components in its composition. Therefore, in our
 study, we aimed to investigate the curative effect of
 ABS on the toxicity of Cd on the lung.
 Material and Method
 Thirty two rats were used in the study, and they were
 divided into 4 groups, with 8 rats in each group:
 control, Kd (2.5 mg/kg single dose ip), ABS (1.5 ml/
 kg single dose ip), and Kd+ABS (Kd, 2,5 mg/kg single
 dose ip-ABS, 1.5 ml/kg single dose ip). Lung tissues
 were evaluated histopathologically. Inflammation
 was evaluated immunohistochemically with tumor
 necrosis factor-α (TNF-α). Oxidative stress was
 evaluated with the total oxidant level (TOS) and total
 antioxidant level (TAS) using the spectrophotometric
 method. Apoptosis was evaluated using RT-PCR with
 relative mRNA fold changes of Bcl-2-associated X
 (Bax), B-cell lymphoma 2 (Bcl-2), cytochrome c (Cyt
 c), and caspase 3 genes.
 Results
 Histopathological findings such as congestion,
 hemorrhage, and mononuclear cell infiltration were
 found to increase in the Cd group. It was found that
 Cd increased inflammation by increasing TNF-α,
 increasing TOS and OSI, and decreasing TAS,
 causing an increase in oxidative stress. (p
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