Anil Kumar and R.K. Singh

Abstract

Abstract-Fabaceae (Caesalpiniaceae)IntroductionIndia is one of the richest countries among the world in resources of medicinal plants in various sytems 1,2like Ayurveda, Siddha, Unani, etc. The treatment of patients with these medicinal plants is increasing 3from previous to till dates. The all medicinal plants contain several biochemical or chemical active substances that show a definite physiological action on human or animal body while applying as -The present communication is based on herb, namely, Cassia fistula. belonging to family for the prevention of intoxication induced with a sublethal dose of Carbon tetrachloride (CCL). Male mice with a dose 4weighing around 6.5 mg/kg body weight were exposed to CCl, a common toxic agent used for 4hepatotoxicity. Seed and leaves extracts of Cassia fistulawere given thereafter to the male mice to check their effect on the toxicity of CCl.After 4several weeks of exposure to these herbal extracts, there was a significant change observed in the biochemical parameters with a significant increase in values of serum oxaloacetatate transferase, serum glutamate pyruvate transferase, gamma-glutamyl transferase, alkaline phosphatase, creatine kinase, creatinine, glucose, and cholesterol. In contrast, no significant statistical difference was perceived in the values of all biochemical parameters in mice treated with leave and seed extracts, except the value of serum cholesterol in mice treated with seed extract which decreased as compared to the control group. These findings suggest the importance of the seeds and leaves and their combined usage against CCl4toxicity, thus promising these plant products to be promising therapeutic agents against hepatotoxicity, cardiotoxicity,nephrotoxicity,andmetabolicdisorders due to CCltoxicity. This also makes the 4safety of herbal products an important public health issue.