Abstract
Single nucleotide polymorphisms (SNPs) in renin-angiotensin system (RAS) genes are associated with RAS imbalance and chronic kidney disease (CKD). We performed a case-control study and meta-analysis to investigate the association between angiotensinogen (AGT) M235T polymorphism and CKD. A total of 634 patients with end-stage renal disease and 739 healthy controls were studied. We also searched PubMed and the Cochrane Library to identify prospective observational studies published before December 2015. We found that the TT and MT genotypes were associated with a higher risk of CKD than the MM genotype (odds ratio [OR]: 3.56; 95% confidence interval [CI]: 1.14–11.16 and OR: 2.93; 95% CI: 0.91–9.46, respectively). Thirty-eight study populations were included in the meta-analysis. The T allele was associated with a higher risk of CKD than the M allele in all populations (OR: 1.19; 95% CI: 1.08–1.32). The OR was 1.33 in Asians (95% CI: 1.06–1.67) and 1.10 in Caucasians (95% CI: 1.02–1.18). Evaluation of gene-gene and gene-environment interactions using epistasis analysis revealed an interaction between AGT M235T and angiotensin II receptor type 1 A1166C in CKD (OR: 0.767; 95% CI: 0.609–0.965). Genetic testing for CKD in high-risk individuals may be an effective strategy for CKD prevention.
Highlights
Renal function gradually decreases in chronic kidney disease (CKD) patients resulting in end-stage renal disease (ESRD)
We found that the TT and MT genotypes were associated with a higher risk of CKD than the MM genotype
Evaluation of gene-gene and geneenvironment interactions using epistasis analysis revealed an interaction between AGT M235T and angiotensin II receptor type 1 A1166C in CKD (OR: 0.767; 95% confidence intervals (CIs): 0.609–0.965)
Summary
Renal function gradually decreases in chronic kidney disease (CKD) patients resulting in end-stage renal disease (ESRD). The C803T polymorphism (rs699) has been frequently reported in previous studies It is located at amino acid 235 in exon 2 and has two possible alleles (M and T). A meta-analysis verified that individuals with the T allele had a higher risk of hypertension [14] and heart disease [16] compared to those with the M allele This locus may be associated with CKD. Previous meta-analyses have investigated the association between AGT M235T and diabetic nephropathy [14, 17], IgA neuropathy [18], and ESRD [19]. These meta-analyses only included data for 9,000 patients. We performed a large-scale case-control study and meta-analysis to investigate the association between AGT M235T and CKD
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call