ANGIOLEIOMYOMA OF THE ORAL CAVITY: REPORT OF 4 NEW CASES

Abstract

Angioleiomyoma (ALM) is a benign smooth muscle tumor that occasionally affects the oral cavity, mainly the lips and hard palate of adults. We report the clinicopathologic features of 4 new cases of oral ALM. There were 2 women and 2 men with mean age of 54 years (range, 34–73 years). The clinical presentation of tumors was asymptomatic, slow-growing small nodules with color varying from normal to bluish, affecting the lower lip, hard palate, lingual frenulum, and maxillary fold. Microscopically, proliferation of fascicles of smooth muscle cells with pale, eosinophilic, and vacuolated cytoplasm and elongated nuclei were observed in a whorled pattern around a central endothelium-lined space. All patients were submitted to conservative surgical removal, and no signs of recurrence were observed. Oral ALM is uncommon and should be considered in the clinical differential diagnosis of solitary dome-shaped nodules of the oral cavity. Angioleiomyoma (ALM) is a benign smooth muscle tumor that occasionally affects the oral cavity, mainly the lips and hard palate of adults. We report the clinicopathologic features of 4 new cases of oral ALM. There were 2 women and 2 men with mean age of 54 years (range, 34–73 years). The clinical presentation of tumors was asymptomatic, slow-growing small nodules with color varying from normal to bluish, affecting the lower lip, hard palate, lingual frenulum, and maxillary fold. Microscopically, proliferation of fascicles of smooth muscle cells with pale, eosinophilic, and vacuolated cytoplasm and elongated nuclei were observed in a whorled pattern around a central endothelium-lined space. All patients were submitted to conservative surgical removal, and no signs of recurrence were observed. Oral ALM is uncommon and should be considered in the clinical differential diagnosis of solitary dome-shaped nodules of the oral cavity.