Abstract

Described herein is a young man with polyarteritis nodosa in whom the clinical picture during life could be related to vascular changes as demonstrated by roentgenography, muscle biopsy, ophthalmoscopy and Clinicophysiologic studies. Angiography was found to be of great diagnostic value and disclosed multiple intracerebral, pulmonary and renal aneurysms. Clinicophysiologic methods made it possible to quantify the functional disorders of several organs. Thus pulmonary function tests revealed moderate, restrictive pulmonary disease, and cardiac catheterizations revealed moderate pulmonary hypertension, probably mainly due to coexistent mitral stenosis. The patient had pronounced intermittent claudication due to occlusion of the right popliteal artery, and physiologic methods also showed signs of circulatory disturbances in the other extremities. A favorable, bilateral effect of physical training on the circulation in the lower extremities was demonstrated. The concurrence of polyarteritis nodosa and rheumatic heart disease is also discussed herein from an etiologic and pathogenetic point of view.

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