Abstract
The aim of this study was the effects of supplementing qi and herbs that promote neovascularization on angiogenesis and expressions of vascular endothelial growth factor and endostatin protein in experimentally induced acute myocardial infarction in rats. Left anterior descending coronary artery was ligated to establish the acute myocardial infarction model. Microvascular vascular count and expressions of vascular endothelial growth factor and endostatin protein were detected and indexes were detected at 7th, 14th and 28th day. The results showed large doses of qi herbs combined with small doses of activating herbs are superior to other groups in promoting the angiogenesis, increasing vascular endothelial growth factor protein expressions and reducing endostatin protein expressions. It also showed that there was a dose-response effect of supplementing qi and activating blood circulation herbs promoting angiogenesis. The mechanism of supplementing qi and activating blood circulation herbs and combination of both promoted angiogenesis due to possibly to increased vascular endothelial growth factor protein expressions and reduced endostatin protein expressions.
Highlights
Myocardial angiogenesis is one of the important mechanisms of myocardial protection
Therapeutic angiogenesis has become a focus of research to treat vasomotor factor that could regulate and balance angiogenesis and neovascularization in the infarct (Koyama, 2011), providing possibly hope for the treatment of acute myocardial infarction through therapeutic angiogenesis
Large doses of qi herbs combined with small doses of activating herbs are 50 micron Sham group
Summary
The state of blood vessels is closely related to the presence of rapid generation in areas of vascular infarction. This approach is to promote new vessel formation and enhance or establish collateral circulation in infarcts. Coronary artery bypass graft and percutaneous transluminal coronary angioplasty had helped to increase blood perfusion of myocardial infarction (Halkos et al, 2011). These invasive approaches are found to be less effective in treating dispersed fine or deep lesions in coronary arteries. Therapeutic angiogenesis has become a focus of research to treat vasomotor factor that could regulate and balance angiogenesis and neovascularization in the infarct (Koyama, 2011), providing possibly hope for the treatment of acute myocardial infarction through therapeutic angiogenesis
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