Abstract
Local AnestheticsLocal anesthetics can be administered by local or regional injection to provide anesthesia during surgery. Regional injection of local anesthetics is used for major nerve block and for spinal (subarachnoid) or epidural block. Although local anesthetics are among the most widely used anesthetic agents and have a good record of clinical safety, questions about their toxicity have recently been raised.The amide local anesthetics (lidocaine, mepivacaine, and bupivacaine) have replaced the esters (e.g., procaine) because of their stability and the fact that they do not cause allergic reactions. Because of its high lipid solubility and high affinity for . . .
Published Version
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