Abstract
IT WAS BUSINESS as usual for Brian Weiser. It had been several minutes since he’d administered propofol, a potent general anesthetic, and one of his charges just refused to go under. Most didn’t budge in response to a quick tap. But one quickly darted away. “He’s slowing down,” Weiser told his supervisor, University of Pennsylvania Perelman School of Medicine anesthesiologist Roderic G. Eckenhoff. “But he’s still got a startle reflex.” So Weiser made a few adjustments, filling a widemouthed glass pipette with a solution of propofol in pond water and adding some to his charges’ plastic dish. “There’s always one resistant tadpole,” he said, gently tapping the petri dish on his laboratory benchtop. Medicinal chemists are used to using model species to test their compounds. Some go with mice, others rats, still others zebrafish. But for people like Eckenhoff and Weiser, a Penn pharmacology graduate student, the search for drugs is, and requires, a different ...
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