Abstract
Incorporation of a (U)14C-amino acid mixture in vivo into total mitochondrial protein was measured as a function of time of androgen or vehicle administration in male sex accessory tissue and liver of normal and castrate rats. In the accessory tissue of castrates, significant increases (2-fold) in mitochondrial protein labeling were noted as early as 6 hr after androgen stimulation. Labeling reached maximal levels (6- to 9-fold) by 24 hr after a single injection of hormone and well before tissue weight increases were noted. Thereafter, protein labeling in the mitochondria of castrate animals plateaued at the same elevated levels between 24 and 72 hr, when additional daily injections of hormone were given. Castrate animals receiving equivalent amounts of vehicle alone showed low incorporation values that were not changed by the experimental procedure. In normal animals, incorporation values in accessory tissue mitochondria were comparable to the highest values seen in treated castrate animals and were not ...
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call