Abstract
The population of Han Chinese is ∼1.226 billion people. Genetic heterogeneity between northern Han Chinese (N-Han) and southern Han Chinese (S-Han) has been demonstrated by recent genome-wide studies. As an initial step toward health disparities and personalized medicine in Chinese population, this study developed a set of ancestry informative markers (AIM) for Han Chinese population.
Highlights
Han Chinese compose the largest ethnic group in the world, which accounts for 91.51% of the Chinese population, or 1.226 billion people, according to China’s 2010 census
A Genetic association study (GAS) may gain additional statistical power by correcting for population stratification, as shown by our previous study that showed that estimation of the genetic effect for candidate loci could be biased by population divergence (He et al 2008)
We developed a set of ancestry informative markers (AIM) for genetic studies of Han Chinese populations
Summary
Hui-Qi Qu,*,1 Quan Li,† Shuhua Xu,‡ Joseph B. Fisher-Hoch,* Momiao Xiong,§ Ji Qian,** and Li Jin‡,**,††,1 *School of Public Health, University of Texas Health Science Center at Houston, Brownsville, Texas 78520, †Endocrine Genetics Lab, McGill University Health Center (Montreal Children’s Hospital), Montréal, Québec H3H 1P3, Canada, ‡Chinese Academy of Sciences and Max Planck Society (CAS-MPG) Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People’s Republic of China, §School of Public Health, University of Texas Health Science Center at Houston, Houston, Texas 77030, **State Key Laboratory of Genetic Engineering and Ministry of Education (MOE) Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, People’s Republic of China, and ††China Medical City (CMC) Institute of Health Sciences, Taizhou, Jiangsu 225300, People’s Republic of China
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