Abstract
The excretory duct length and secretory coil size of microdissected eccrine sweat glands of children with fatal chronic renal disease, cystic fibrosis, and congenital heart disease were compared with those of a control series. Patients with chronic renal disease had small sweat glands compared with controls matched for age, whereas older children with congenital heart disease had long sweat gland ducts compared with controls, and patients with cystic fibrosis had normal glands. The reduced size of the sweat glands of patients with chronic renal insufficiency demonstrates that the factor(s) causing nephron hypertrophy in kidneys with increased work loads do not stimulate growth of eccrine sweat glands. The increase in sweating reported for patients with failure-prone forms of congenital heart disease is not reflected in enlargement of sweat glands demonstrable by the methods employed in this study.
Published Version
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