Anatomic resection, surgical margin positivity and primary tumor site do not have effect on overall survival after liver resection for colorectal metastases

Abstract

Introduction: Liver resection performed for colorectal cancer liver metastases prologs survival even in cases of resectable extrahepatic disease. Several factors that related to disease and operation are advocated to provide survival benefit in this patient group. In here we present our ten year experience of resections performed for CRCLMs. Method: One hundred and eight patients were operated for CRCLM between January 2007 and January 2017 at Ankara University Hospitals. Patient and disease characteristics and overall survival data were obtained retrospectively from hospital records. Overall survival of patients were compared according to gender, primary tumor site, tumor T status if it was T4, liver resection type if it was anatomic resection, preoperative chemotherapy, metastasis presentation and surgical margin positivity with Log-rank Test. Overall 1, 3 and 5 year survival of all patients were calculated. Result: None of the variables mentioned above were found to have significant effect on overall survival in our cohort (p>0.05). Surgical margin negative patients, patients with metachronously presented liver metastasis and patients underwent anatomic liver resections have a non significant tendency for better survival. One-year, 3 year and 5 year survival rates were calculated 88.1%, 53.7% and 40.6% respectively. Conclusion: Although large series are needed for evaluation of these factors on survival, according to our patient cohort disease related factors and surgical approach does not have effect on survival. This Result may be the greater effect of chemotherapies on stage 4 disease. Resections performed at our center resulted comparable outcomes.