Abstract
† Rocuronium may be associated with a higher incidence when compared with other NMBDs. † After accounting for Results. Rocuronium was responsible for 56% of cases of NMBD anaphylaxis, succi- nylcholine 21%, and vecuronium 11%. There was no difference in the severity of reactions for different NMBDs. Rocuronium had a higher rate of IgE-mediated ana- phylaxis compared with vecuronium (8.0 vs 2.8 per 100 000 exposures; P¼0.0013). The prevalence of cross-reactivity after NMBD anaphylaxis suggested that succinylcholine also has a high risk of triggering anaphylaxis. Cisatracurium had the lowest prevalence of cross-reactivity in patients with known anaphylaxis to rocuronium or vecuronium. Conclusions. Rocuronium has a higher rate of IgE-mediated anaphylaxis compared with vecuronium, a result that is statistically significant and clinically important. Cisatracurium had the lowest rate of cross-reactivity in patients who had previously suffered anaphylaxis to rocuronium or vecuronium.
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