Abstract
Aim: The purpose of this study is to examine the total antioxidant capacity (TAC) as a biomarker to investigate oxidative stress in different pathological conditions. The primary goal is to compare the TAC levels in saliva before and after the restoration of carious teeth. Additionally, the study aims to explore potential differences in TAC between genders with the intention of establishing a possible link between salivary TAC and dental caries. Materials and Methods: In this research, we employed a random selection process to assemble two cohorts: Group I, comprising 27 male individuals, and Group II, encompassing 27 females, all falling within the age bracket of 7 to 10 years. Saliva samples were procured from each participant both thirty days prior to and subsequent to the restorative dental intervention. To gauge the levels of total antioxidant capacity (TAC), we employed Cayman’s antioxidant assay kit and quantified the outcomes employing a nanodrop instrument. Results: The obtained data was subjected to statistical analysis using SPSS version 18.0. The paired t-test was used to compare the TAC levels before and after the restorative procedure within each group (Group I and Group II). The results revealed that after restoration, both Group I and Group II showed a significant increase in TAC levels compared to before restoration (P = 0.000). Additionally, the Student t-test was employed to compare the TAC levels between Group I (males) and Group II (females). Interestingly, the study observed that the TAC of saliva was significantly higher in males compared to females, both before and after the restoration of carious teeth. Conclusion: Our research demonstrated reduced TAC levels in areas affected by dental caries, and these levels exhibited a significant rise following the restoration of all carious teeth. Consequently, it can be deduced that the evaluation of caries activity and the effectiveness of its treatment can be facilitated through the assessment of salivary factors, which holds promise for applications in preventive dentistry. Clinical Significance: TAC can be employed as a biomarker and a therapeutic target because a reduced TAC level before restoration is a sign of infection.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
