Abstract
Objective Exploring the characteristics of prefrontal cortex activation in patients of major depressive disorder (MDD) combined with anxiety and obsession through functional near-infrared spectroscopy (fNIRS). Methods Prefrontal cortex hemoglobin concentration exchange of 30 MDD patients combined with anxiety and obsession was detected by fNIRS under voice fluency task(VFT), then psychological assessment was made using Hanmilton Depression Scale(HAMD), Hamilton Anxiety Scale(HAMA) and Symptom Checklist 90(SCL-90). The exchange and assessment scores were compared. Results (1) Compared with control group, the decreased Oxy-Hb exchange was confirmed in lateral and lower prefrontal cortex in MDD patients (P<0.05);(2) Oxy-Hb exchange in right-lateral prefrontal cortex were associated with the severity of anxiety（r=0.370,0.380， both P<0.05）, while that in bilateral prefrontal cortex and antero-medial prefrontal cortex were associated with severity of depression（r=0.391,0.375,0.403,0.492,0.396,0.362,0.384，all P<0.05）. And no statistical correlation was observed between severity of obsession and prefrontal cortex. Conclusion It indicated hypoactivation state of prefrontal cortex was in MDD patients, while the severity of anxiety and depression may be associated with right-lateral prefrontal cortex, bilateral and antero-medial prefrontal cortex. Key words: Spectroscopy，near-infrared; Prefrontal cortex; Verbal fluency task; Emotion; Depressive disorder; Anxiety; Obsession behavior
Published Version
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