Abstract
In order to gain a better theoretical understanding of the interaction between voltage and calcium influx, we present the simulation results for saltatory transmission in a sparsely excitable model of a continuous cylindrical segment of nerve fiber, where calcium diffuses internally and various ion channels are distributed as hotspots along the cable. A standard set of ion channel descriptions is used to illustrate how different numbers and distributions of ion channel hotspots affect the propagation and transmission of a single action potential and/or a spike train and how such hotspots affect calcium influx and diffusion within continuous cylindrical segment of nerve fiber.
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