Abstract
Simple and sensitive methodology to monitor the dissolution rate of norethindrone-mestranol combination tablets has been developed. The procedure calls for the direct injection of the dissolution medium onto a reverse-phase column and for the monitoring of the eluent serially with ultraviolet and fluorescence detectors. Applicability of the method was demonstrated by carrying out dissolution studies of a combination product in de-aerated water and 30% isopropanol/water.
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